Project

Posted on:

Arthropods Research Laboratories

Studio of Metropolitan Design Architects

Project Name

Arthropods Research Laboratories

Location

Smilow Center for translational Research


3400 Civic Center Boulevard




19104

Project Status

Built

Year Completed

2014

Size

1,000 sq. feet

Client/Owner

Perelman School of Medicine University of Pennsylvania

Consultants

  • : AKF Engineering
  • Electrical Engineer: AKF Engineering
  • Plumbing Engineer: AKF Engineering


Certifications and Designations



View all (3) images

Project Description

The laboratory is located on the 9th floor of the Translational Research Center part of the University of Pennsylvania Perelman Center for Advanced Medicine. The laboratory, designed by the architects at Studio of Metropolitan Design, is biologically secure and constructed specifically to study arthropods, in particular Carpenter ants Camponotus floridanus and Camponotus tortuganus and the Indian jumping ant Harpegnathos saltator.

Major objectives and activities (arthropods, plant pathogens, noxious weeds, biological control agents, etc.)

The facility will be used for research into the epigenetic basis of the behavior and aging of ants. For example, we will measure and compare aspects of chromatin structure along with gene expression levels among ants grouped by caste, behavioral repertoire, age, etc. We will also deliver drugs to ants orally or by injection to attempt to manipulate behavior and lifespan.

The carpenter ants Camponotus floridanus and Camponotus tortuganus are relatively large (5-10mm) arboreal ant species that are endemic throughout the state of Florida, USA. They prefer habitating in decomposing wood found in moist environments, such as coastal drift wood. The jumping ant Harpegnathos saltator is a large (~20mm) carnivorous ant found in India, Sri Lanka, and Southeast Asia.

This species belongs to a subfamily in which caste specialization, in particular reproductive division of labor, is limited. Consequently, non-reproductive workers can transition into a reproductive developmental state following death or removal of an existing reproductive queen from the colony.

The epigenetics of behavior and longevity in ants:
The laboratory of Shelley Berger focuses on mechanisms that regulate gene expression with a special emphasis on how the DNA-packaging structure of chromatin is manipulated during genomic processes. The lab has recently begun to investigate how chromatin structure regulates complex phenotypes at the whole-organism level using ants as a model. Ants provide an excellent study system because individuals within a colony are highly related genetically but exhibit striking differences in morphology, behavior, and longevity.
Advertisement
Add A Projectweaetxdyvaydzcwq
Publish Your Projects Show off and upload images, text, and video of your work. We pick the very best for our project newsletters. Upload

Join the Discussion

Please read our Content Guidelines before posting

Close X